THE NETHERLANDS – FEBRUARY 18, 2014 – SynAffix B.V., a protein engineering company focusing on the creation of next-generation Antibody-Drug Conjugates (ADCs), today announced the completion of its Series A investment round. Investors in the round are Aravis SA (Switzerland), BioGeneration Ventures (the Netherlands), MS Ventures, the corporate venture capital fund of Merck Serono and BOM Capital (the Netherlands).
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Bring your own and/or choose from the following categories.
Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.
Early preclinical data available on request.
NK cell recruitment
NK cell recruitment
Forming an integral part of every toxSYN®
linker-payload, HydraSpace® bears a negative charge at physiological pH and improves:
GlycoConnect™ design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).
| toxSYN® Linker-Payload |
Mode-of-Action | Payload (Active Catabolite) |
|---|---|---|
| 1. SYNtecan E™* | Topoisomerase 1 inhibitor | Camptothecin-based |
| 2. SYNeamicin D™* | DNA damaging agent |
Calicheamicin-based |
| 3. SYNeamicin G™* | ||
| 4. SYN-PNU™* | Nemorubicin-based | |
| 5. SYNstatin E™ | Microtubule inhibitors |
Auristatin-based |
| 6. SYNstatin F™ | ||
| 7. SYNtansine™ | Maytansine-based |
* Patent protection filed by Synaffix, beyond the claims of GlycoConnect™ and HydraSpace®
** N-6-aminohexanoyl-maytansine (Ahx-maytansine)
