About

Synaffix is a biotech company with a clinical-stage platform technology that enables best-in-class antibody-drug conjugates (ADCs), bispecific antibodies and other targeted therapeutics under a technology out-licensing business model.  Synaffix was fully acquired by Lonza in June 2023.

Aimed at enabling innovative medicines for patients in areas of high unmet medical need, Synaffix has forged a growing number of collaborations with top tier biotech and pharma companies by enabling best-in-class therapeutic candidates for their pipelines.

Company Timeline

Deal with Macrogenics (NASDAQ:MGNX)
Synaffix signs out-licensing deal with Macrogenics worth up to $586m
February 2022
Deal with Genmab (NASDAQ:GMAB)
Synaffix signs exclusive out-licensing deal with Genmab worth up to $415m
January 2022
Deal with Mersana (NASDAQ:MRSN) Expanded
Synaffix expands the 2019 deal with Mersana to over $1 billion.
November 2021
Deal with Kyowa Kirin (TYO:4151)
Kyowa Kirin Taps Synaffix ADC Technology to Expand Its Pipeline
August 2021
Deal with ProfoundBio
Synaffix signs out-licensing deal with ProfoundBio worth up to $246m
July 2021
Deal with Innovent (1801:HK)
Synaffix signs out-licensing deal with Innovent, providing access to GlycoConnect™, HydraSpace™ and toxSYN™ platforms for ADC development and commercialization
June 2021
Winner "Best ADC Platform Technology" Award
Synaffix awarded “Best ADC Platform Technology” at World ADC Awards ceremony
Sept 2020
Deal with Miracogen
Synaffix signs out-licensing deal with Miracogen worth up to $125m
Apr 2019
Deal with Mersana (NASDAQ:MRSN)
Synaffix signs out-licensing deal with Mersana worth up to $295m
Jan 2019
toxSYN™ Linker-Payloads Launched
Synaffix launches toxSYN™ linker-payloads as extension of its existing platform, enabling any company with an antibody to develop proprietary, best-in-class ADCs
Dec 2017
Deal with ADC Therapeutics (NYSE:ADCT)
Synaffix signs initial out-licensing deal with ADC Therapeutics, providing access to GlycoConnect™ and HydraSpace™ for ADC development and commercialization
Oct 2016
High Potency Lab Opens
High potency lab comes online, facilitating safe handling of highly-potent ADCs and ADC payloads
Feb 2016
SAB Established
Leading industry experts appointed to Scientific Advisory Board (SAB)
Jan 2016
Series A Financing
Series A financing, backed by top-tier investor syndicate including Aravis, BioGeneration Ventures, BOM Capital and M Ventures
Feb 2014

Protein Conjugates

Bring your own and/or choose from the following categories. 

 

Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.

 

Early preclinical data available on request.

Bring Your Own

scFv / Fab
Cytokine

Immune Cell Recruiters

Anti-CD3

T cell recruitment
IL-15

NK cell recruitment

IL-15 Receptor Fusion

NK cell recruitment

HydraSpace™ Polar Spacer

Forming an integral part of every toxSYN™ linker-payload, HydraSpace™ bears a negative charge at physiological pH and improves:

  1. Therapeutic efficacy
  2. Tolerability
  3. PK
  4. Manufacturability
Key publication about HydraSpace

GlycoConnect™ design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).

Key publications about GlycoConnect™

toxSYN™ Linker-Payloads

Choose from the following linker-payloads, attach to your antibody under a technology evaluation and go straight into ADC product development following positive POC.
toxSYN™
Linker-Payload
Mode-of-Action Payload
(Active Catabolite)
1. SYNtecan E™*Topoisomerase 1 inhibitor Camptothecin-based
2. SYNeamicin D™*DNA
damaging agent
Calicheamicin-based
3. SYNeamicin G™*
4. SYN-PNU™*Nemorubicin-based
5. SYNstatin E™Microtubule
inhibitors
Auristatin-based
6. SYNstatin F™
7. SYNtansine™ Maytansine-based

* Patent protection filed by Synaffix, beyond the claims of GlycoConnect™ and HydraSpace™

** N-6-aminohexanoyl-maytansine (Ahx-maytansine)