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Director Organic Chemistry

Prime objective of the R&D group is to provide best-in-class ADC technologies, spanning from development of conjugation technologies to linkers and payloads. Main focus currently is on cytotoxic ADCs, however next-generation technologies for application immune-oncology and targeted gene therapy are an important company ambition. The associate director organic chemistry plays an active role in shaping and defining the company’s R&D agenda and ensuring successful execution thereof.

Job Description

  • Identifies key growth areas in the field of conjugation chemistries and translates these into new R&D projects
  • Recognizes trends/opportunities in potential growth fields
  • Analyzes strengths and weaknesses of technologies of key competitors
  • Engages with internal and external IP-counsels to support and strengthen patent portfolio
  • Chairs internal organic chemistry work-meetings and discussions
  • Coordinates project management in multi disciplinary teams, related to project definition, budgeting and project execution
  • Supports business development team in partnering discussions and strategy
  • Scouts and performs or delegates auxiliary tasks
  • Ensures operational excellence within the chemistry group related to laboratory and equipment maintenance and EHS matter.
  • Organizes in-house trainings/conferences
  • Coaches and inspires organic chemistry R&D staff (direct & indirect reports)
  • Perform other duties as assigned

Skills

  • Analysis and mapping of early technology development trends in targeted therapies
  • Lab work related: able to interpret NMR, RP-HPLC, TLC, IR
  • Strong scientific background with proven track record in the field of organic chemistry
  • Ability to solve complex chemical problems
  • Experience with in project drafting and budgeting
  • People management
  • Strong organizational skills

Apply here

https://lonza.wd3.myworkdayjobs.com/Lonza_Careers/job/NL—Oss/Director-Organic-Chemistry_R58456-1

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Protein Conjugates

Bring your own and/or choose from the following categories. 

 

Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.

 

Early preclinical data available on request.

Bring Your Own

scFv / Fab
Cytokine

Immune Cell Recruiters

Anti-CD3

T cell recruitment
IL-15

NK cell recruitment

IL-15 Receptor Fusion

NK cell recruitment

HydraSpace™ Polar Spacer

Forming an integral part of every toxSYN™ linker-payload, HydraSpace™ bears a negative charge at physiological pH and improves:

  1. Therapeutic efficacy
  2. Tolerability
  3. PK
  4. Manufacturability
Key publication about HydraSpace

GlycoConnect™ design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).

Key publications about GlycoConnect™

toxSYN™ Linker-Payloads

Choose from the following linker-payloads, attach to your antibody under a technology evaluation and go straight into ADC product development following positive POC.
toxSYN™
Linker-Payload
Mode-of-Action Payload
(Active Catabolite)
1. SYNtecan E™*Topoisomerase 1 inhibitor Camptothecin-based
2. SYNeamicin D™*DNA
damaging agent
Calicheamicin-based
3. SYNeamicin G™*
4. SYN-PNU™*Nemorubicin-based
5. SYNstatin E™Microtubule
inhibitors
Auristatin-based
6. SYNstatin F™
7. SYNtansine™ Maytansine-based

* Patent protection filed by Synaffix, beyond the claims of GlycoConnect™ and HydraSpace™

** N-6-aminohexanoyl-maytansine (Ahx-maytansine)