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Bring your own and/or choose from the following categories.Â
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Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.
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Early preclinical data available on request.
NK cell recruitment
NK cell recruitment
Forming an integral part of every toxSYNÂŽ
linker-payload, HydraSpaceÂŽ bears a negative charge at physiological pH and improves:
GlycoConnect⢠design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).
| toxSYNÂŽ Linker-Payload |
Mode-of-Action | Payload (Active Catabolite) |
|---|---|---|
| 1. SYNtecan Eâ˘* | Topoisomerase 1 inhibitor | Camptothecin-based |
| 2. SYNeamicin Dâ˘* | DNA damaging agent |
Calicheamicin-based |
| 3. SYNeamicin Gâ˘* | ||
| 4. SYN-PNUâ˘* | Nemorubicin-based | |
| 5. SYNstatin E⢠| Microtubule inhibitors |
Auristatin-based |
| 6. SYNstatin F⢠| ||
| 7. SYNtansine⢠| Maytansine-based |
* Patent protection filed by Synaffix, beyond the claims of GlycoConnect⢠and HydraSpaceŽ
** N-6-aminohexanoyl-maytansine (Ahx-maytansine)
