Centered entirely around the antibody glycan, Synaffix has established a simple, rapidly deployable technology platform, enabling any company with an antibody to develop a proprietary, best-in-class ADC or bispecific.
Under a focused technology out-licensing business model, Synaffix has delivered multiple best-in-class therapeutic candidates for our partners’ pipelines.
Bring your own and/or choose from the following categories.
Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.
Early preclinical data available on request.
NK cell recruitment
NK cell recruitment
Forming an integral part of every toxSYN®
linker-payload, HydraSpace® bears a negative charge at physiological pH and improves:
GlycoConnect™ design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).
toxSYN® Linker-Payload |
Mode-of-Action | Payload (Active Catabolite) |
---|---|---|
1. SYNtecan E™* | Topoisomerase 1 inhibitor | Camptothecin-based |
2. SYNeamicin D™* | DNA damaging agent |
Calicheamicin-based |
3. SYNeamicin G™* | ||
4. SYN-PNU™* | Nemorubicin-based | |
5. SYNstatin E™ | Microtubule inhibitors |
Auristatin-based |
6. SYNstatin F™ | ||
7. SYNtansine™ | Maytansine-based |
* Patent protection filed by Synaffix, beyond the claims of GlycoConnect™ and HydraSpace®
** N-6-aminohexanoyl-maytansine (Ahx-maytansine)